Ondansetron blocks the actions of chemicals in the body that can trigger nausea and vomiting. Ondansetron is used to prevent nausea and vomiting that may be caused by surgery or by medicine to treat cancer (chemotherapy or radiation). Ondansetron may be used for purposes not listed in this medication guide.
Zuplenz (Ondansetron) is a medication in the drug class of 5HT3 receptor or serotonin antagonists. Zuplenz works by blocking the action of chemicals in the body that can trigger nausea and vomiting caused by cancer therapy. Zuplenz is usually applied on top of the tongue where it will dissolve in 4 to 20 seconds and then swallowed with saliva.