The average Zegerid cash price is about $3,322.23 for a supply of: Packet 40-1680 MG 30 pcs. Get our free Zegerid coupon and be eligible to receive a discount. You can reduce your Zegerid cost by up to 75% with our free Zegerid discount card. Bring it to a participating pharmacy near you to save on your prescription medication.Treating heartburn or irritation of the esophagus caused by gastroesophageal reflux disease (GERD). It may also be used for short-term treatment of ulcers of the stomach or small intestine. It may also be used to decrease the risk of stomach bleeding in severely ill patients. It may also be used for other conditions as determined by your doctor. Zegerid is a proton pump inhibitor (PPI) and sodium bicarbonate combination. The PPI works by decreasing the amount of acid produced in the stomach. The sodium bicarbonate works by slowing the breakdown of the PPI in the stomach, which helps to increase absorption of the PPI.