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Tizanidine is a drug that belongs to the central alpha-adrenergic agonist class of drugs. Tizanidine is typically used to block the pain sensations sent by the nerve impulses during muscle spasms. Tizanidine works by relaxing the muscles and in doing so it can treat muscle pain brought about by certain conditions like multiple sclerosis. Tizanidine is used to treat lower back pains, muscle spasms and cramps.