Dihydroergotamine is in a group of drugs called ergot alkaloids (ER-got AL-ka-loids). It works by narrowing the blood vessels around the brain and affects blood flow patterns that are associated with certain types of headaches. Dihydroergotamine injection is used to treat a migraine or cluster headache attack. This medication will only treat a headache that has already begun. It will not prevent headaches or reduce the number of attacks. Dihydroergotamine injection should not be used to treat common tension headaches or any headache that seems to be different from your usual migraine headaches. Dihydroergotamine is not for daily use. Dihydroergotamine injection may also be used for purposes not listed in this medication guide.
Migranal is prescribed to treat symptoms of migraine headaches. It does this by entering the brain and shrinking blood vessels, which helps relieve migraines. Its mechanism primarily agonizes the 5-HT receptors in the brain to do this, but it also interacts with the adrenergic and dopamine receptors.