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Fluoxetine is a prescription medication belonging to a class of drugs known as selective serotonin reuptake inhibitors (SSRIs). Fluoxetine is a generic drug; the brand names for fluoxetine or Prozac, Prozac weekly, Rapiflux, Sarafem, and Selfemra. Fluoxetine is used to treat depression, panic attacks, premenstrual disorders, and other conditions. Fluoxetine works by inhibiting CNS neuronal uptake of serotonin.