Understanding brain chemistry has allowed scientists to understand mental disease at an ever greater level. Duloxetine is one of these products, as it is used to treat a variety of depressive and anxiety-related illnesses. But, its efficacy does not stop there. Duloxetine is also licensed for use in those who experience peripheral neuropathy as a consequence of diabetes. It's also prescribed for those who suffer from fibromyalgia and urinary incontinence. This wide variety of indications derived from its mechanism of action. As an SNRI, it prevents the reuptake of serotonin and norepinephrine at certain brain sites. This means more serotonin and norepinephrine is available at the fundamental levels of the brain.