Tacrolimus is used together with other medicines to prevent the body from rejecting a transplanted organ (eg, kidney, liver, or heart). This medicine may be used with steroids, azathioprine (Imuran®), basiliximab (Simulect®), or mycophenolate mofetil (Cellcept®). Tacrolimus belongs to a group of medicines known as immunosuppressive agents. When a patient receives an organ transplant, the body's white blood cells will try to get rid of (reject) the transplanted organ. Tacrolimus works by suppressing the immune system to prevent the white blood cells from trying to get rid of the transplanted organ.
Astagraf XL decreases the action of the immune system, which helps the body to fight infections and foreign bodies. This can increase the chances of developing cancer, including lymphoma skin cancer. The immune system is also known to fight and reject a transplanted organ especially liver and kidney transplants. Astagraf XL is used by doctors together with other medicine to prevent the body from rejecting a heart, liver or kidney transplant.