The average Vicodin cash price is about $49.75 for a supply of: Tablet 5-300 MG 90 pcs. Get our free Vicodin coupon and be eligible to receive a discount. You can reduce your Vicodin cost by up to 75% with our free Vicodin discount card. Bring it to a participating pharmacy near you to save on your prescription medication.Hydrocodone is an opioid pain medication. An opioid is sometimes called a narcotic. Acetaminophen is a less potent pain reliever that increases the effects of hydrocodone. Acetaminophen and hydrocodone is a combination medicine used to relieve moderate to severe pain. Acetaminophen and hydrocodone may also be used for purposes not listed in this medication guide.