Teniposide is a cancer medication that interferes with the growth and spread of cancer cells in the body. Teniposide is used to treat acute lymphoblastic leukemia (a type of blood cancer) in children. Teniposide is usually given after other cancer medications have been tried without successful treatment. Teniposide may also be used for purposes not listed in this medication guide.
Teniposide is a semisynthetic derivative of podophyllotoxin, a cytotoxic agent that is indicated for treatment of childhood acute lymphocytic leukemia (ALL). These agents inhibits DNA gyrase (type II topoisomerase) activity and thus blocks DNA synthesis and arrest growth of cancer cells in the body. It is usually used in combination with other anticancer agents.