Get our free Sotret coupon and be eligible to receive a discount. You can reduce your Sotret cost by up to 75% with our free Sotret discount card. Bring it to a participating pharmacy near you to save on your prescription medication.Isotretinoin is a form of vitamin A. It reduces the amount of oil released by oil glands in your skin, and helps your skin renew itself more quickly. Isotretinoin is used to treat severe nodular acne that has not responded to other treatments, including antibiotics. Isotretinoin may also be used for purposes not listed in this medication guide.