Pristiq is a strong medicine that should be handled carefully. Do not take it if you have venlafaxine, desvenlafaxine and other allergies from Pristiq ingredients. It should also not be taken by someone who has been taking MAOI drugs for the past 14 days. After about seven days of taking Pristiq, one can then take an MAOI. Pristiqis used in treating severe migraines as well as psychiatric disorders to avoid a syndrome referred to as serotonin which is life-threatening. Check out our Pristiq discounts and coupons to start saving on your next prescription.