Premarin Vaginal cream contains a mixture of estrogen hormones. Estrogen is a female sex hormone produced by the ovaries. Estrogen is necessary for many processes in the body. Premarin Vaginal cream is used to treat the vaginal symptoms of menopause such as dryness, burning, irritation, and painful sexual intercourse. Premarin Vaginal cream should not be used to prevent heart disease or dementia, because this medication may actually increase your risk of developing these conditions. Premarin Vaginal may also be used for purposes not listed in this medication guide.