Pegaptanib is made from a human antibody fragment. It works by keeping new blood vessels from forming under the retina (a sensory membrane that lines the inside of the eye). In people with a certain type of eye disease, new blood vessels grow under the retina where they leak blood and fluid. This is known as the "wet form" of macular degeneration. Pegaptanib ophthalmic (for the eyes) is used to treat wet age-related macular degeneration. Pegaptanib ophthalmic may also be used for purposes not listed in this medication guide.
Macugen (pegaptanib) is a drug often prescribed to treat macular degeneration, a disorder related to the retina of the eye. Macugen is a Category B pregnancy drug, meaning that it has not been known to indicate any risk to individuals. Macugen is an ophthalmic anti-angiogenic, or vascular endothelial growth factor directed antibody used to slow the growth of blood vessels in the eye.