Hydrocodone is an opioid pain medication. An opioid is sometimes called a narcotic. Ibuprofen is a non steroidal anti inflammatory drug (NSAID). This medicine works by reducing substances in the body that cause pain, fever, and inflammation. Hydrocodone and ibuprofen is a combination medicine is used short-term to relieve severe pain. This medication is not for treating arthritis pain. Hydrocodone and ibuprofen may also be used for purposes not listed in this medication guide.