Levoleucovorin is used to treat or prevent toxic effects of methotrexate in people who have received methotrexate to treat bone cancer. Levoleucovorin is also used to treat or prevent toxic effects of methotrexate in people whose bodies do not eliminate methotrexate properly after the drug is metabolized. Levoleucovorin may also be used to treat toxic effects of an accidental overdose of methotrexate. Levoleucovorin is also used in combination chemotherapy with fluorouracil (5-FU, Adrucil, Efudex, Carac, Fluoroplex) to treat colorectal cancer that has spread to other parts of the body. Levoleucovorin treats only the symptoms of colorectal cancer but does not treat the cancer itself. Levoleucovorin should not be used to treat anemia that is caused by a lack of vitamin B12. Levoleucovorin may also be used for purposes not listed in this medication guide.
Fusilev is used to lower the effects of methotrexate and other medicines such as folic antagonists. Fusilev is usually prescribed to help manage the side effects of chemotherapy. Fusilev belongs to a class of drugs known as folic acid derivative and may be used to treat other conditions as determined by the doctor. Fusilev is administered under a doctor's prescription.