When used with carbidopa and levodopa (Atamet, Parcopa, Sinemet), entacapone increases levels of levodopa in the body. Entacapone is used together with carbidopa and levodopa to treat "wearing-off" symptoms of Parkinson's disease, such as stiffness, tremors, muscle spasms, and poor muscle control. Entacapone may also be used for purposes not listed in this medication guide.
Entacapone is a drug that falls in the class of catechol-O-methyltransferases commonly referred to as COMT. This inhibitor is used in the treatment of Parkinson's disease among other major conditions that it is responsible for. It is effective especially when mixed with other dopaminergic agents for instance L-DOPA. Entacapone can be used as elaborated below.