Dofetilide is a heart rhythm medicine, also called an antiarrhythmic. Dofetilide is used to help keep the heart beating normally in people with certain heart rhythm disorders of the atrium (the upper chambers of the heart that allow blood to flow into the heart). Dofetilide is used in people with atrial fibrillation or atrial flutter. Dofetilide may also be used for purposes not listed in this medication guide.
Dofetilide is a class III antiarrhythmic agent used to treat specific types of irregular heartbeat that is atrial fibrillation or atrial flutter in certain patients. Dofetilide works by aiding the heart to regain a normal rhythm by selectively closing potassium efflux which in turn causes the refractory period of atrial tissue to increase.