Colchicine affects the way the body responds to uric acid crystals, which reduces swelling and pain. Because colchicine was developed prior to federal regulations requiring FDA review of all marketed drug products, not all uses for colchicine have been approved by the FDA. As of 2009, Colcrys is the only brand of colchicine that has been approved by the FDA. The Colcrys brand of colchicine is FDA-approved to treat gout in adults, and to treat a genetic condition called Familial Mediterranean Fever in adults and children who are at least 4 years old. Generic forms of colchicine have been used to treat or prevent attacks of gout, or to treat symptoms of Behcets syndrome (such as swelling, redness, warmth, and pain). Colchicine is not a cure for gouty arthritis or Behcets syndrome, and it will not prevent these diseases from progressing. Colchicine should not be used as a routine pain medication for other conditions. Colchicine may also be used for purposes not listed in this medication guide.
Colchicine is predominantly used in the treatment of gout but is also prescribed for conditions such as Behcet's disease and aphthous stomatitis. Colchicine is also prescribed for those with constipation-predominant irritable bowel syndrome. Colchicine works by inhibiting microtubule formation as well as inhibition of neutrophil activity. As a consequence, it serves to reduce inflammation, a common symptom seen in gout. Colchicine is well tolerated though some patients have reported experiencing severe allergic reactions. Should you experience any unwelcome side-effects, take the time to report to your prescriber at the first opportunity.
Colchicine is a drug used in the treatment of gout. The drug is a natural product of the autumn crocus plant, known as Colchicum autumnale. Colchicine has also been used in the treatment of other inflammatory conditions such as Behcet's disease, relapsing polychondritis, and - in rare cases - irritable bowel syndrome.
Colchicine works by binding to tubulin - a structural component of microtubules. Microtubules are needed by cells to retain their structural integrity. Colchicine also disrupts neutrophil activity, leading to a pronounced anti-inflammatory effect.
Colchicine is associated with numerous side effects, many of which patients find intolerable. For example, patients may experience nausea, vomiting, abdominal pain, diarrhea, fever, anemia, and numbness in the hands and feet.