The average Bufferin extra strength cash price is about $11.36 for a supply of: Tablet 500 MG 30 pcs. Get our free Bufferin extra strength coupon and be eligible to receive a discount. You can reduce your Bufferin extra strength cost by up to 75% with our free Bufferin extra strength discount card. Bring it to a participating pharmacy near you to save on your prescription medication.Aspirin is a salicylate (sa-LIS-il-ate). It works by reducing substances in the body that cause pain, fever, and inflammation. Aspirin is used to treat pain, and reduce fever or inflammation. Aspirin is sometimes used to treat or prevent heart attacks, strokes, and chest pain (angina). Aspirin should be used for cardiovascular conditions only under the supervision of a doctor. Aspirin may also be used for purposes not listed in this medication guide.