Aspirin and caffeine is a salicylate (sa-LIS-il-ate). It works by reducing substances in the body that cause pain, fever, and inflammation. Caffeine is used in this product to increase the pain relieving effects of aspirin and caffeine. Aspirin and caffeine is a combination product used to treat headaches, muscle pain, minor arthritis pain, and fever or body aches caused by the common cold. Aspirin and caffeine is sometimes used to treat or prevent heart attacks, strokes, and chest pain (angina). Aspirin and caffeine should be used for cardiovascular conditions only under the supervision of a doctor. Aspirin and caffeine may also be used for purposes not listed in this medication guide.