Rosiglitazone is an oral diabetes medicine that helps control blood sugar levels. Rosiglitazone is for people with type 2 diabetes. Rosiglitazone is sometimes used in combination with other medicines, but it is not for treating type 1 diabetes. Rosiglitazone is not recommended for use with insulin. Taking rosiglitazone while you are using insulin may increase your risk of serious heart problems. Taking rosiglitazone may increase your risk of serious heart problems, such as heart attack or stroke. Therefore, rosiglitazone is available only to certain people with type 2 diabetes that cannot be controlled with other diabetes medications. Rosiglitazone may also be used for purposes not listed in this medication guide.