Fibrin sealant is made of two substances from human plasma that work together to help your blood clot. Fibrin sealant topical is used to help control bleeding during surgery when other ways to close a wound or incision (such as stitches, bands, or heat) cannot be used. Fibrin sealant topical may also be used to prevent leaks from a wound left in stomach tissue after a colostomy is removed. Fibrin sealant topical is sometimes used to help skin tissues stick together during skin graft procedures or cosmetic surgery. Fibrin sealant topical may also be used for purposes not listed in this medication guide.