Amphotericin B liposomal is an antifungal antibiotic that fights infections caused by fungus. Amphotericin B liposomal is used to treat serious, life-threatening fungal infections including leishmaniasis, and a certain form of meningitis in people infected with HIV (human immunodeficiency virus). Amphotericin B liposomal is not for treating a minor fungal infection such as a yeast infection of the mouth, esophagus, or vagina. Amphotericin B liposomal may also be used for purposes not listed in this medication guide. Ambisome, also called amphotericin B liposomal, is in the drug class of polyenes. This prescription medication is used to treat serious fungal infections such as meningitis. Ambisome is a common medication that is taken overseas to less developed countries. This is because these serious fungal infections are much more common than in more wealthy countries such as the United Kingdom or the United States. Ambisome can be administered through the veins via an IV. There is no capsule or tablet for Ambisome because the condition of the patient is often too severe to warrant a slow drug regime. The IV is often the fastest and most effective manner of delivering the medication.