Clioquinol topical fights bacteria and prevents fungus from growing on your skin. Hydrocortisone is a topical steroid. It reduces the actions of chemicals in the body that cause inflammation. Clioquinol and hydrocortisone is a combination medicine used to treat skin infections caused by fungus (such as ringworm or jock itch) and skin conditions such as eczema. Clioquinol and hydrocortisone may also be used for purposes not listed in this medication guide.