Advair is a combination of Fluticasone and salmeterol and belongs to a group of drugs known as Bronchodilator combinations. Advair is used to prevent the release of substance in the body that cause inflammation. The drug works by relaxing muscles in the airway to improve breathing. This is by reducing the swelling and irritation of the airway forcing the muscles to relax. Advair has to be used regularly to be effective. This medication is administered by mouth through inhalation twice a day.