The average Anacin cash price is about $11.76 for a supply of: Tablet 400-32 MG 30 pcs. Get our free Anacin coupon and be eligible to receive a discount. You can reduce your Anacin cost by up to 75% with our free Anacin discount card. Bring it to a participating pharmacy near you to save on your prescription medication.Aspirin and caffeine is a salicylate (sa-LIS-il-ate). It works by reducing substances in the body that cause pain, fever, and inflammation. Caffeine is used in this product to increase the pain relieving effects of aspirin and caffeine. Aspirin and caffeine is a combination product used to treat headaches, muscle pain, minor arthritis pain, and fever or body aches caused by the common cold. Aspirin and caffeine is sometimes used to treat or prevent heart attacks, strokes, and chest pain (angina). Aspirin and caffeine should be used for cardiovascular conditions only under the supervision of a doctor. Aspirin and caffeine may also be used for purposes not listed in this medication guide.