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Ondansetron blocks the actions of chemicals in the body that can trigger nausea and vomiting. Ondansetron is used to prevent nausea and vomiting that may be caused by surgery or by medicine to treat cancer (chemotherapy or radiation). Ondansetron may be used for purposes not listed in this medication guide.Zofran ODT (Ondansetron) is a drug that is recommended by doctors after surgery or for patients going through chemotherapy or radiotherapy. Zofran ODT is used to put a stop to the queasiness and vomiting that is normally a result of cancer medication. Zofran ODT works by blocking chemicals that elicit queasiness and vomiting.
