Get our free Premarin vaginal coupon and be eligible to receive a discount. You can reduce your Premarin vaginal cost by up to 75% with our free Premarin vaginal discount card. Bring it to a participating pharmacy near you to save on your prescription medication.Premarin Vaginal cream contains a mixture of estrogen hormones. Estrogen is a female sex hormone produced by the ovaries. Estrogen is necessary for many processes in the body. Premarin Vaginal cream is used to treat the vaginal symptoms of menopause such as dryness, burning, irritation, and painful sexual intercourse. Premarin Vaginal cream should not be used to prevent heart disease or dementia, because this medication may actually increase your risk of developing these conditions. Premarin Vaginal may also be used for purposes not listed in this medication guide.