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Mefloquine is a medicine used to treat malaria, a disease caused by parasites. This medicine works by interfering with the growth of parasites in the red blood cells of the human body. Parasites that cause malaria typically enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Mefloquine is also used to prevent malaria. Mefloquine may also be used for purposes not listed in this medication guide.