Get our free Mefloquine hydrochloride coupon and be eligible to receive a discount. You can reduce your Mefloquine hydrochloride cost by up to 75% with our free Mefloquine hydrochloride discount card. Bring it to a participating pharmacy near you to save on your prescription medication.Mefloquine is a medicine used to treat malaria, a disease caused by parasites. This medicine works by interfering with the growth of parasites in the red blood cells of the human body. Parasites that cause malaria typically enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Mefloquine is also used to prevent malaria. Mefloquine may also be used for purposes not listed in this medication guide.