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Treating symptoms of advanced prostate cancer. It may also be used for other conditions as determined by your doctor. Lupron Depot is a gonadotropin-releasing hormone (GnRH) agonist. It works by decreasing levels of certain hormones produced by the testes and ovaries. This prevents the growth of certain tumors that need these hormones to grow.Lupron Depot (leuprolide) is a prescription drug which is used for the treatment of the symptoms of advanced prostate cancer. Lupron Depot, a gonadotropin-releasing hormone (GnRH) agonist, inhibits the production of testosterone (male sex hormone) that causes testosterone-dependent prostate cancer cells to grow. Prostate cancer is manageable if Lupron Depot treatment plan is strictly followed and regularly monitored.