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Clotrimazole is an antifungal antibiotic that treats or prevents infection caused by fungus. Betamethasone is a topical steroid that reduces itching, swelling, and redness of the skin. The combination of betamethasone and clotrimazole topical is used to treat fungal skin infections such as athlete's foot, jock itch, and ringworm. Betamethasone and clotrimazole topical may also be used for other purposes not listed in this medication guide.Lotrisone cream contains a mixture of clotrimazole and betamethasone. Clotrimazole is an antifungal, which helps in fighting infections resulting from fungus. The other medication, betamethasone is a steroid that reduces swelling, redness of the skin and itching. This medication is used to treat fungal skin infections like jock itch, ringworm and athlete's foot.