The average Lastacaft cash price is about $245.93 for a supply of: Solution 0.25 % 3 Bottle. Get our free Lastacaft coupon and be eligible to receive a discount. You can reduce your Lastacaft cost by up to 75% with our free Lastacaft discount card. Bring it to a participating pharmacy near you to save on your prescription medication.Alcaftadine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms such as itchy or watery eyes. Alcaftadine ophthalmic (for the eyes) is used to prevent itching in the eyes caused by allergies. Alcaftadine ophthalmic should not be used to treat eye irritation caused by contact lenses. Alcaftadine ophthalmic may also be used for purposes not listed in this medication guide.