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Treating tension headaches. It may also be used for other conditions as determined by your doctor. Fiorinal with Codeine is a salicylate, barbiturate, caffeine, and narcotic combination. How these medicines work is not completely understood. Aspirin reduces pain and inflammation. Caffeine may work by constricting blood vessels that may cause headaches. Butalbital has a depressant effect that reduces anxiety and causes relaxation. Codeine works in the central nervous system to decrease pain.Fiorinal with codeine is a combination of drug products that is used to treat tension headaches. Fiorinal consists of a mixture of caffeine, butalbital, and aspirin in different ratios performing different roles in the treatment of several illnesses. Codeine is readily absorbed in the blood and does not accumulate in the body tissues.