Fentanyl is an opioid pain medication. An opioid is sometimes called a narcotic. Fentanyl buccal is used to treat "breakthrough" cancer pain that is not controlled by other medicines. Fentanyl buccal is taken together with other non-fentanyl narcotic pain medicine that is used around the clock. Fentanyl buccal is not for treating pain that is not cancer-related, such as pain from surgery or dental work, migraine headaches, or back pain. Fentora is available only under a special program called the TIRF REMS Program. You must be registered in the program and understand the risks and benefits of taking this medication. Fentanyl buccal may also be used for purposes not listed in this medication guide.