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Bicalutamide is an anti-androgen. It works in the body by preventing the actions of androgens (male hormones). Bicalutamide is used together with another hormone to treat prostate cancer. Bicalutamide may also be used for purposes not listed in this medication guide.Bicalutamide is a medication used to treat prostate cancer in men. It works by binding to the androgen receptor and preventing its action, thus decreasing the action of androgenic hormones in the body. These are male hormones that act in the prostate, and blocking their action slows the growth of the tumor.