The average Aczone cash price is about $647.80 for a supply of: Gel 7.5 % 60 Pump Btl. Get our free Aczone coupon and be eligible to receive a discount. You can reduce your Aczone cost by up to 75% with our free Aczone discount card. Bring it to a participating pharmacy near you to save on your prescription medication.Aczone is indicated for the topical treatment of acne vulgaris based on Dapsone topical. Dapsone topical is an anti infective medication used to help treat acne. Aczone is for topical use only. Not for oral, ophthalmic, or intravaginal use. How to use Aczone: After the skin is gently washed and patted dry, apply approximately a pea-sized amount of ACZONE in a thin layer to the acne affected areas twice daily. Rub in ACZONE gently and completely. ACZONE is gritty with visible drug substance particles. Wash hands after application. If there is no improvement after 12 weeks, treatment with ACZONE should be reassessed. Dapsone topical may also be used for purposes other than those listed in this medication guide.